Pathology
（第六版教材 -第四版课件）
Lijiang Liu （刘丽江）
刘丽江 （ 1955-） 医学学士
病理学与病理生理学教研室 主任 教授
硕士生导师
1982年毕业于武汉医师进修学院
享受国务院和武汉市政府专项津贴
市管优秀专家
现任,中国病理学工作者委员会 副主任委员
中国抗癌协会肿瘤转移专业委员会 常委
中国抗癌协会湖北分会肿瘤病理委员会 常委
中华医学会湖北省病理学会 常委
中华医学会武汉病理学会 副主任委员
department of pathology
主要研究方向：
胃癌淋巴结转移
结直肠癌与乳癌的转移
病理学教学及教学评价研究
主要研究成果：
获武汉市科技进步二、三等奖 4 项
正式发表论文 52 篇
department of pathology
department of pathology
办公室,J12-C202
电话,027-84226503
027-51259966
027-82411803（汉口校区）
E-mail,liulijiang@netease.com
department of pathology
Introduction
to
pathology
department of pathology
disease?
? disease can be define as any condition
? that the presence of an
abnormality of the body
cause a loss of normal
health
Pathology?
is the scientific study of disease
the metabolism
the functional
the morphological
changes
occur during
the course of
the disease
department of pathology
general pathology (1~5 chapter)
? the mechanisms and
characteristics of the principal
types of disease process
systemic pathology (6~16 chapter)
? the descriptions of specific
disease as they affect individual
organs or systems
department of pathology
Pathology include:
Pathoanatomy:
anatomical method disease
Pathophysiology:
physiological method disease
In china:
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Histopathology—
? the study of histological
abnormalities of disease
cells and tissues
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Haematology—
? the study of
primary or secondary
disease of the blood
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Chemical pathology—
the study of
biochemical abnormalities
associated with disease
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Microbiology—
the study of infectious
disease and organism that
cause them
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
immunopathology—
the study of disease
through analysis of
immune function
department of pathology
total of to say,Pathology:
? clinical pathology ---
diagnosis of disease
? experimental pathology ---
animal models
? molecular pathology ---
gene and gene product
department of pathology
department of pathology
total of to say,Pathology:
? clinical pathology
(human pathology)
(surgical pathology)
clinical pathology
department of pathology
Clinical pathology
department of pathology
The animal experiments
department of pathology
molecular pathology
department of pathology
gene and gene
product
Molecular pathology
department of pathology
Molecular pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
especially in the autopsy,
with unaided eye
an important
investigative method
Now:
It is obvious to reduce
department of pathology
Autopsy diagram
autopsy
department of pathology
autopsy
department of pathology
autopsy
department of pathology
男,59 岁。
晨 6时发现死
在值班室内。
autopsy
department of pathology
autopsy
department of pathology
Autopsies:
determining the cause of death
audit of clinical diagnosis
education
research into the causes and
mechanism of disease
gathering accurate statistics
about disease incidence
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
? especially in the biopsy
an important method of
clinical diagnosis
? eye + light microscopy
(HE stain)
department of pathology
biopsy
department of pathology
biopsy
department of pathology
biopsy
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
histochemistry
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
immuohistochemistry and
immunofluorescence
employ antibody to visualise substances in tissue sections or
cell preparations
antibody linked chemically to enzymes or fluorescent colour
reaction
department of pathology
immunohistochemistry stain
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
cell cultures
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
in situ hybridisation
in situ polymerase chain reaction
? to render the presence of specific
genes or their mRNA visible in tissue
section or cell preparations
? in situ hybridisation
minute quantities of nucleic acids
? in situ PCR
molecular pathology
department of pathology
new technique,
flow cytometry
image analysis
laser microdissection
tissue microarrage
department of pathology
flow cytometry
department of pathology
image analysis
department of pathology
laser microdissection
department of pathology
tissue microarrage technology
department of pathology
Pathology development history
Gross section
microscopy
immunohistochemistry
Anatomy pathology
History pathology
Cellular pathology
Molecular pathology
DNA,RNA and
Protein analysismolecular pathology
department of pathology
department of pathology
department of pathology
teaching arrangement
total,112 (learn the hours)
theories lesson,60
experiment lesson,36
restrict elective lesson,16
department of pathology
restrict elective lesson:
Histopathological technique
Normal regulations technique
Special staining technique
immunohistochemcal technique
Clinical pathological discussion
8-10 clinical cases
(clinical pathological conference)
department of pathology
examination way
written test +
personal interview/operation
theories lesson,50%
experiment lesson,30%
restrict elective lesson,20%
department of pathology
written test:
word explains 20%
essay question 20%
brief question 15%
choice question 40%
Translation 5%
department of pathology
Bibliography
1.ROBBINS BASIC PATHOLOGY 7th edition
2.SYSTEMYPATHOLGY 2th edition
3.武忠弼主编, 病理学总论与各论,
（ Allgemeine und spezielle pathologie）
4,O'Connor,Jones,PAHOLOGY
5,Jones,B.J,风暴式医学教程, 病理学,
department of pathology
（第六版教材 -第四版课件）
Lijiang Liu （刘丽江）
刘丽江 （ 1955-） 医学学士
病理学与病理生理学教研室 主任 教授
硕士生导师
1982年毕业于武汉医师进修学院
享受国务院和武汉市政府专项津贴
市管优秀专家
现任,中国病理学工作者委员会 副主任委员
中国抗癌协会肿瘤转移专业委员会 常委
中国抗癌协会湖北分会肿瘤病理委员会 常委
中华医学会湖北省病理学会 常委
中华医学会武汉病理学会 副主任委员
department of pathology
主要研究方向：
胃癌淋巴结转移
结直肠癌与乳癌的转移
病理学教学及教学评价研究
主要研究成果：
获武汉市科技进步二、三等奖 4 项
正式发表论文 52 篇
department of pathology
department of pathology
办公室,J12-C202
电话,027-84226503
027-51259966
027-82411803（汉口校区）
E-mail,liulijiang@netease.com
department of pathology
Introduction
to
pathology
department of pathology
disease?
? disease can be define as any condition
? that the presence of an
abnormality of the body
cause a loss of normal
health
Pathology?
is the scientific study of disease
the metabolism
the functional
the morphological
changes
occur during
the course of
the disease
department of pathology
general pathology (1~5 chapter)
? the mechanisms and
characteristics of the principal
types of disease process
systemic pathology (6~16 chapter)
? the descriptions of specific
disease as they affect individual
organs or systems
department of pathology
Pathology include:
Pathoanatomy:
anatomical method disease
Pathophysiology:
physiological method disease
In china:
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Histopathology—
? the study of histological
abnormalities of disease
cells and tissues
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Haematology—
? the study of
primary or secondary
disease of the blood
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Chemical pathology—
the study of
biochemical abnormalities
associated with disease
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
Microbiology—
the study of infectious
disease and organism that
cause them
department of pathology
Pathology include:
1,Histopathology
2,Haematology
3,Chemical pathology
4,Microbiology
5,Immunopathology
In west:
department of pathology
immunopathology—
the study of disease
through analysis of
immune function
department of pathology
total of to say,Pathology:
? clinical pathology ---
diagnosis of disease
? experimental pathology ---
animal models
? molecular pathology ---
gene and gene product
department of pathology
department of pathology
total of to say,Pathology:
? clinical pathology
(human pathology)
(surgical pathology)
clinical pathology
department of pathology
Clinical pathology
department of pathology
The animal experiments
department of pathology
molecular pathology
department of pathology
gene and gene
product
Molecular pathology
department of pathology
Molecular pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
especially in the autopsy,
with unaided eye
an important
investigative method
Now:
It is obvious to reduce
department of pathology
Autopsy diagram
autopsy
department of pathology
autopsy
department of pathology
autopsy
department of pathology
男,59 岁。
晨 6时发现死
在值班室内。
autopsy
department of pathology
autopsy
department of pathology
Autopsies:
determining the cause of death
audit of clinical diagnosis
education
research into the causes and
mechanism of disease
gathering accurate statistics
about disease incidence
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
? especially in the biopsy
an important method of
clinical diagnosis
? eye + light microscopy
(HE stain)
department of pathology
biopsy
department of pathology
biopsy
department of pathology
biopsy
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
histochemistry
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
immuohistochemistry and
immunofluorescence
employ antibody to visualise substances in tissue sections or
cell preparations
antibody linked chemically to enzymes or fluorescent colour
reaction
department of pathology
immunohistochemistry stain
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
cell cultures
department of pathology
methods of pathology:
1,gross pathology
2,light microscopy
3,histochemistry
4,immunohistochemistry
and immunofluorescence
5,electron microscopy
6,cell cultures
7,molecular pathology
department of pathology
in situ hybridisation
in situ polymerase chain reaction
? to render the presence of specific
genes or their mRNA visible in tissue
section or cell preparations
? in situ hybridisation
minute quantities of nucleic acids
? in situ PCR
molecular pathology
department of pathology
new technique,
flow cytometry
image analysis
laser microdissection
tissue microarrage
department of pathology
flow cytometry
department of pathology
image analysis
department of pathology
laser microdissection
department of pathology
tissue microarrage technology
department of pathology
Pathology development history
Gross section
microscopy
immunohistochemistry
Anatomy pathology
History pathology
Cellular pathology
Molecular pathology
DNA,RNA and
Protein analysismolecular pathology
department of pathology
department of pathology
department of pathology
teaching arrangement
total,112 (learn the hours)
theories lesson,60
experiment lesson,36
restrict elective lesson,16
department of pathology
restrict elective lesson:
Histopathological technique
Normal regulations technique
Special staining technique
immunohistochemcal technique
Clinical pathological discussion
8-10 clinical cases
(clinical pathological conference)
department of pathology
examination way
written test +
personal interview/operation
theories lesson,50%
experiment lesson,30%
restrict elective lesson,20%
department of pathology
written test:
word explains 20%
essay question 20%
brief question 15%
choice question 40%
Translation 5%
department of pathology
Bibliography
1.ROBBINS BASIC PATHOLOGY 7th edition
2.SYSTEMYPATHOLGY 2th edition
3.武忠弼主编, 病理学总论与各论,
（ Allgemeine und spezielle pathologie）
4,O'Connor,Jones,PAHOLOGY
5,Jones,B.J,风暴式医学教程, 病理学,
department of pathology
