Hemorrhogic Fever Virus
Dept,of microbiology and parasitology
Hantaar Virus or HEMORRHAGIC FEVER with
renal syndrome virus ( HFRS）
Xing Jiang Hemorrhogic Fever Virus
Hantaar Virus
(HEMORRHAGIC FEVER with renal
syndrome virus )
? Spherical,80-120nm
? Nucleocapsid,Helical,
3 segments,2 proteins
- nucleocapsid ('N'),
RNA polymerase ('L')
? Envelope,2
glycoproteins,G1 and
G2,
Morphology
Biological properties
1,ssRNA with long,medium,short segments
2,Antigens 6 serotypes (I- VI)
3,Resistance,weak
Epidemiology
1,Natural host, rodents (deer mouse
(Peromyscus maniculatus),cotton rat
(Sigmodon hispidus),marsh rice rat (Oryzomys
palustris),white-footed mouse (Peromyscus
leucopus),other carriers)
2,Transmission, Droplet and rodent excreta
spread
3,Season and district
Clinical syndromes
? Headache;
? Pink in face,neck
? Fever
? marked bleeding tendency
? Lower blood pressure
? Urine with Protein
? multi-organ failure
Pathogenicity
Clinical manifestations,
5 phases
? Fever phase
? Hypotension phase
? Auria phase
? Polyuria phase
? convalescent phase
? Pathogenesis
? Viral direct damage
? Immunopathogenesis
? Laboratory diagnosis
? Cultivation,Vero-E6 cell and A549 cell
? Serological diagnosis,IgM/IgG
indirect immunofluorescent assay
ELISA-IgM
? Inactivated vaccine
Xing Jiang Hemorrhogic Fever
Virus
? Spherical,80-120nm
? Nucleocapsid,Helical,
3 segments,2 proteins
- nucleocapsid ('N'),
RNA polymerase ('L')
? Envelope,2
glycoproteins,G1 and
G2,
? Vector and Host
? Animal Host
? Hyalomma asiaticum
? Season,April and May
? Inactivated vaccine