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B?8?;μB?1" ???M]¥?aéF[ uY -?? °"]÷t orthologuesa?? ?"]÷t  paralogues b °"]÷?a¥? 1?1s0 ID4 Z_b t f ?/ ?¨yé? ? ¥ZE V[£ U% )a? ? ??t-W ^?ta ? ?±t-W¥1"b?t1 "o ?Vs0 £ ü? ?¤[? üb 6BZ ? ?"]÷?a¥ù?Xüé?¥ =? 4 ?1 ' ?¥L ìb ?"]÷?a ^?]B?yü ??ˉ?7??bˉ? ?¤yü ? ò1¥é?o??t?YVMs? a?7á 3b yF = ?"]÷?as?¥? V ?μ? ?¤??z¥3 db ? j,£é  Rhodopsin ?EB s8×s?  T ^ ?"]÷?a¥B? è0 Henikoff ? 1997b ? ??aé μM?<W¥? ? ? j $aP $a? $a í? *ü.?¥ s8bYV? 1 V[ ???yˉ?7á 3¥?]? ??B?b è ?,?té?V?* ùs ?7¤?¥?] j $ s8  Opsins ?]¥oé ù?b |£;? s; ù?¥ò?éo s8-W uY?v ? M]?1 95%P· 7D oé¥ ?; s8 j,£éd ? ? s8Mμ?ù ü (1 43%b?? ?N¥ ?"]÷?a?°"]÷?a ?á 3¥?  ˉ? ^?aéEBs ?ù?¥B? vG^b 1.13 8yT?¥ 4? ? s¥?1 4? ^ ??V?  ? ?s 3tDilb ?"]÷?°"]÷ ?? ]¥é?? Pù5M¤÷Fˉb ??V?  ? o ? ì ?¤2T?4 |? ??i dBq^ Yb?9 ???1? 3?¥? ?? d ??  ^p¥ 7?tp2TXü ????  ? o?i ?-7 ? ?b " - ?s?? ?? dé?é  e?¥μrZEb ?I¥??9 ?¥ P¨íP EsA1 ?7? ?G ?9 ? ? é?1?) ? μ .¥2Bb ?? M ??o K??s u× Hs2T¥3 dü÷Fˉb??aé  vs  H- 31?ib ?ì?aé  v ^·?aé? ? V??? ?|??í¥ ?? ? b ?aé  v V[ AT ^F??aé2×¥'?ê9 ^?aé¥'/?êb ?] Lego ! vB"YV?M]?]¥'  v¥ò?F??? ?N¥o ómp [???aé¥ò??]? ?bVL.D¥4? A?t  v? ?? ?¥s?? ^e ?¥yˉ?? μ?7 ^? ?y ?  gene shuffling?á 3¥b ?] Jacob 1977 M í ?¥ *"?5 8V? ??o1 ?p`B? F?? eüò Tò"¥?à ?"  ? ???Bq?¨Ib A ?é?V?i?? ^Vh 7 S7 ^ ?¨Cμ? YV?/ P á 3?¥? ?? ^ü+??]¥"d???B ??÷z¥?"db e?q¥ ?¨??? ^÷va÷ˉ"d?á 3?¥a?;? ¥?? ?¥1ob ; ? ?N ^? V[?X?¥e?q???8? ?$Lm¥ ^????¥? ? q1μ Kb? ^y1 V[?F? ?"d¥?q¥+? ?3 dB?ˉ"d ?? ???t?q ¥+?w??"d¥?8+?b? 3tDE ? a? V ?? ts0WMoT¨¥  3w?? 3?"d¥ˉ?b á ì¨B?ü? Rube Goldberg ó? a ü??ˉ¥ 3t"d¥ 4 m  1-3b? ? ó? !9¤dè F ó' P ? 95%?q¥T¨ ^X?9? 4w 6? 5%???q ¥? ? 3t"dü^B?1ˉ¥ ó?b Jacob ·?? t } ?¥? t? aé  v$¨? ? ìeμ¥? ?Xü?Mb?t  vé?V??$??  ? = ?i/ ?¥μ8?b ?" HW¥wMá ìG ? V[OY *t* ù? ?¥? ?? 4 N7w?¥? ?b?t4???¥? ???aM ?? ? ì? ??é?1" HA??  ?ibA7^n ?¨ ?DZE£ Uˉ"d?ò?s-W¥1"X1é?¥ ? ·μB ? ? M¥ 3üA?? ü 3 V?¥%?b á ì|o 訥k?°"? ?"]÷1"¥+?? 1ZE· ? ìi¥ù 5bD5 μM?¥ 4s? -W¥é?1"G ? Esμ¨y1 V[¨N ? ?? ? ì ^? μM]¥? ?b ?yF £ ü ù??aé? ? V[¨ ?1??]?8?¥ }?"d? 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