Actinomyces &
Nocardia
Actinomyces
? A.israelii,
A.naeslundii;
? Gram positive;
sulfur granule;
? Related to decay
tooth and
peridentitis
ACTINOMYCES
Anaerobic,filamentous,gram
positive bacillus
? Exhibit true branching
?,Mykes” – Greek for,fungus”
? Thought by early microbiologist to
be fungi because of,
? Morphology
? Disease they cause
Clinical specimens:Actinomycosis-pus
ACTINOMYCOSIS
Not highly virulent
(Opportunist)
? Component of Oral
Flora
? Periodontal pockets
? Dental plaque
? Tonsilar crypts
? Take advantage of
injury to penetrate
mucosal barriers
? Coincident infection
? Trauma
? Surgery
Actinomycosis
? A chronic suppurative and granulomatous肉
芽肿 disease of the cervico-facial,thoracic or
abdominal areas
ACTINOMYCOSIS
Form indurated masses with fibrous
walls and central loculations with
pus
? Pus contains "Sulfur Granules"
? Gritty,yellow white
? Average diameter - 2mm
? Composed of mineralized,mycelial” mass
Chronic infection
? Form burrowing sinus tracts to skin or
mucus membranes
? Discharge purulent material
Actinomycosis - sulfur granule
Pulmonary Actinomycosis
? 15% of cases
? Aspiration of
organism from the
oropaharynx
? Slowly progressive
process involving
lung and pleura
? May be mistaken for
malignancy
? Chest pain,fever,wgt
loss and hemoptysis
Mycetoma
(足菌病）
Streptomyces
species?
Nocardiosis
? Subcutaneous
infections,
pulmonary infections,
and brain abscesses
? N,asteroides; N,
brasiliensis
Lab,Diagnosis
? Clinical
Specimens:Sputum,Pus,Biopsy tissue
Sulfamethoxazole-Trimethoprim