RICKETTSIA
ORIENTIA
EHRLICHIA
ANAPLASMA
COXIELLA
BARTONELLA
General introduction
? Gram-negative,obligate intracellular
coccobacilli bacteria that infect
mammaols and arthropods
? Rickettsiae are transmitted in the
arthropods,which serves as both
vector and reservior
? Both DNA and RNA
? Is sensitive to antibiotic,
Category of rickettsia
? Genus
Rickettsia,Coxiella,Orientia,Ehrlichia Bartonella
? Species
Rickettsia prowazekii (epidemic typhus),
Rickettsia typhi (endemic typhus),Rickettsia
rickettsii (spotted fever),Rochalimaea quintana
(trench fever),Coxiella burnetii (Q fever)
Bilogical features
? Variable shape,
coccobacilli
? Gram negative
? Microcapsule and slim
layer
? Culture, in york sacs of
embryonated eggs
Antigenic structure
? LPS
Rickettsia tsutsugamushi
Coxiella burnetii (Q fever)
LPSⅠ smooth
LPSⅡ rough
Weil-Felix reacrion
? Surface protein(SPA)
Transmission
? Typhus,spotted fever and trench fever are
transmitted via arthropod vectors;
? Q fever is acquired via inhalation or
ingestion of contaminated milk or food,
Pathogenesis
? Virulence factors,endotoxin,
phospholipase A,and slime layer
? Sites,vascular system producing
vasculitis血管炎
? Characteristic triad of symptoms,fever,
headache and rash (no rash with Q fever),
Rickettsia prowazekii
普氏立克次体
? epidemic typhus
? average incubation periods (days):8
? the louse
? Respiratory tract and conjunctiva
? Latent period,2 weeks
? Abrupt onset,fever,chills,headache,
myalgia,arthralgia
Replication cycle of Rickettsia and
Orientia
Rickettsia typhi
地方性斑疹伤寒立克次体
? endemic typhus
? 7-14 days
? Mice
? the louse&flea
? Mouth,nose and conjunctiva
? Gradual onset,fever,headache,myalgia,
cough
Rickettsia tsutsugamushi
恙虫病立克次体
? Tsutsugamushi disease(scrub typhus)
? Mice
? tsutsugamushi
? Black eachar焦痂
Coxiella burnetti贝纳柯斯体
? Q fever
? Cow and sheep
? tick
? High resistance
abrupt
onset,fever,headache,chills,
myalgia,granulomatous
hepatitis
chronic diaease with
subacute
onset,endocarditis,hepatic
dysfunction
Replication of C,burnetii
Generalized Life Cycle of Dermacentor variabilis and
Dermacentor andersoni Ticks
Bartonella henselae汉赛巴通体
? CSD (cat scratch disease)
? Cat and dog
? Conjunctiva inflammation and lymph node
swell
Ehrlichia埃里希体属
? Ehrlichia chaffeensis,human
monocytotropic ehrlichiosis
? Ehrlichia sennetsu, human granulocyto
tropic ehrlichiosis
Replication of Ehrlichia埃里希体
Proposed life cycle for the agent of Human
Granulocytic Ehrlichiosis埃里希体病
Diagnosis
? The use of immunofluorescent antibodies to
examine a biopsy can be diagnostic,
? The organism can be inoculated into tissue
culture and grown over 4-7 days but this is very
hazardous to personnel,
? The Weil-Felix test looks for the production of
serum antibody that is reactive against Proteus
OX19,OX2 or OXK antigens but it is not always
reliable,
Control
? Sanitary,Arthropod and rodent control
? Immunological,No vaccines are
currently available,
? Chemotherapeutic,Tetracycline or
chloramphenicol are drugs of choice,
ORIENTIA
EHRLICHIA
ANAPLASMA
COXIELLA
BARTONELLA
General introduction
? Gram-negative,obligate intracellular
coccobacilli bacteria that infect
mammaols and arthropods
? Rickettsiae are transmitted in the
arthropods,which serves as both
vector and reservior
? Both DNA and RNA
? Is sensitive to antibiotic,
Category of rickettsia
? Genus
Rickettsia,Coxiella,Orientia,Ehrlichia Bartonella
? Species
Rickettsia prowazekii (epidemic typhus),
Rickettsia typhi (endemic typhus),Rickettsia
rickettsii (spotted fever),Rochalimaea quintana
(trench fever),Coxiella burnetii (Q fever)
Bilogical features
? Variable shape,
coccobacilli
? Gram negative
? Microcapsule and slim
layer
? Culture, in york sacs of
embryonated eggs
Antigenic structure
? LPS
Rickettsia tsutsugamushi
Coxiella burnetii (Q fever)
LPSⅠ smooth
LPSⅡ rough
Weil-Felix reacrion
? Surface protein(SPA)
Transmission
? Typhus,spotted fever and trench fever are
transmitted via arthropod vectors;
? Q fever is acquired via inhalation or
ingestion of contaminated milk or food,
Pathogenesis
? Virulence factors,endotoxin,
phospholipase A,and slime layer
? Sites,vascular system producing
vasculitis血管炎
? Characteristic triad of symptoms,fever,
headache and rash (no rash with Q fever),
Rickettsia prowazekii
普氏立克次体
? epidemic typhus
? average incubation periods (days):8
? the louse
? Respiratory tract and conjunctiva
? Latent period,2 weeks
? Abrupt onset,fever,chills,headache,
myalgia,arthralgia
Replication cycle of Rickettsia and
Orientia
Rickettsia typhi
地方性斑疹伤寒立克次体
? endemic typhus
? 7-14 days
? Mice
? the louse&flea
? Mouth,nose and conjunctiva
? Gradual onset,fever,headache,myalgia,
cough
Rickettsia tsutsugamushi
恙虫病立克次体
? Tsutsugamushi disease(scrub typhus)
? Mice
? tsutsugamushi
? Black eachar焦痂
Coxiella burnetti贝纳柯斯体
? Q fever
? Cow and sheep
? tick
? High resistance
abrupt
onset,fever,headache,chills,
myalgia,granulomatous
hepatitis
chronic diaease with
subacute
onset,endocarditis,hepatic
dysfunction
Replication of C,burnetii
Generalized Life Cycle of Dermacentor variabilis and
Dermacentor andersoni Ticks
Bartonella henselae汉赛巴通体
? CSD (cat scratch disease)
? Cat and dog
? Conjunctiva inflammation and lymph node
swell
Ehrlichia埃里希体属
? Ehrlichia chaffeensis,human
monocytotropic ehrlichiosis
? Ehrlichia sennetsu, human granulocyto
tropic ehrlichiosis
Replication of Ehrlichia埃里希体
Proposed life cycle for the agent of Human
Granulocytic Ehrlichiosis埃里希体病
Diagnosis
? The use of immunofluorescent antibodies to
examine a biopsy can be diagnostic,
? The organism can be inoculated into tissue
culture and grown over 4-7 days but this is very
hazardous to personnel,
? The Weil-Felix test looks for the production of
serum antibody that is reactive against Proteus
OX19,OX2 or OXK antigens but it is not always
reliable,
Control
? Sanitary,Arthropod and rodent control
? Immunological,No vaccines are
currently available,
? Chemotherapeutic,Tetracycline or
chloramphenicol are drugs of choice,
