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General Concepts of Renal Disease
2005-3-10
Huashan hospital,Fudan University
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Contents
? Normal anatomy,physiology and metabolism of
the kidney
? Clinical manifestation of renal disease
? Diagnosis and treatment
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Anatomy of the Kidney
? Structure of the kidney
? The nephron
? Renal vasculature
? Interstitium
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The nephron
? Glomerulus
? Bowman’s capsule
? Tubulus
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The glomerulus
? Glomerular endothelium
? The podocytes
? The mesangium
? The filtration barrier
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The Filtration Barrier
? The endothelium
? Glomerular basement membrane
? The podocyte foot process
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Physiology of the Kidney
? Glomerular filtration
? Renal tubular reabsorption
? Kidney and endocrine system
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Clinical Manifestation of Renal Disease
? Edema
? Hypertension
? Flank pain
? Dysuria and frequency
? Oligulia and anuria
? Polyuria and nocturia
? Proteinuria and hematuria
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Clinical Manifestation of Renal Disease
? Pyuria and bacilluria
? Renal insufficiency
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Oliguria
? Prerenal oliguria
? Parenchymatous oliguria
? Postrenal oliguria
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Proteinuria
? Glomerular proteinuria
? Tubular proteinuria
? Overflow proteinuria
? Tissue proteinuria
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Hematuria
? Pattern of hematuria
? Localization of hematuria
? Causes of hematuria
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Laboratory Assessment of Renal Disease
? Urinalysis
? Renal function
? Renal biopsy
? Radiologic assessment
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Diagnosis of Renal Disease
? Etiological diagnosis
? Clinical diagnosis
? Functional diagnosis
? Pathological diagnosis
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Clinical Diagnosis
? Acute glomerulonephritis
? Rapidly progressive glomerulonephritis
? Chronic glomerulonephritis
? Nephrotic syndrome
? Asymptomatic hemturia and/or proteinuria
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Treatment
? Etiological treatment
? Immunological treatment
? Control of infection
? Control of blood pressure
? Management of disorders of fluid and electrolyte
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Treatment
? Dialysis
? Renal transplantation