731
CHAPTER 26
LIPIDS
SOLUTIONS TO TEXT PROBLEMS
26.1 The triacylglycerol shown in text Figure 26.2a, with an oleyl group at C-2 of the glycerol unit and
two stearyl groups at C-1 and C-3, yields stearic and oleic acids in a 2 : 1 molar ratio on hydrolysis.
A constitutionally isomeric structure in which the oleyl group is attached to C-1 of glycerol would
yield the same hydrolysis products.
orCH
3
(CH
2
)
7
CH CH(CH
2
)
7
COCH
CH
2
OC(CH
2
)
16
CH
3
CH
2
OC(CH
2
)
16
CH
3
O
O
O
CH
3
(CH
2
)
16
COCH
O CH
2
OC(CH
2
)
7
CH CH(CH
2
)
7
CH
3
CH
2
OC(CH
2
)
16
CH
3
O
O
3H
2
O
H11001H11001CH
3
(CH
2
)
7
CH CH(CH
2
)
7
COH
O
Oleic acid
HOCH
CH
2
OH
CH
2
OH
Glycerol
2HOC(CH
2
)
16
CH
3
O
Stearic acid
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732 LIPIDS
26.2 The sulfur of acyl carrier protein acts as a nucleophile and attacks the acetyl group of acetyl
coenzyme A.
26.3 Conversion of acyl carrier protein–bound tetradecanoate to hexadecanoate proceeds through the
series of intermediates shown.
26.4 The structure of L-glycerol 3-phosphate is shown in a Fischer projection. Translate the Fischer pro-
jection to a three-dimensional representation.
CH
2
OH
HO H
CH
2
OPO
3
H
2
HCHOH11013 same asH
CH
2
OH
CH
2
OPO
3
H
2
C
HO
CH
2
OH
H
2
O
3
POCH
2
O
CH
3
(CH
2
)
12
CS ACP
O O
CH
3
(CH
2
)
12
CCH
2
CS ACP
OOH
CH
3
(CH
2
)
12
CHCH
2
CS ACP
O
HO
2
CCH
2
CS ACP
O
CH
3
(CH
2
)
12
CH
2
CH
2
CS ACP
O
CH
3
(CH
2
)
12
CH ACPCHCS
CH
3
CSCoA HSCoACH
3
CCH
3
CSHS
ACP
ACP H11001H11001
O O
ACPSCoA
S
O
H
Acetyl
coenzyme A
Acyl carrier
protein
Tetrahedral
intermediate
S-Acetyl acyl
carrier protein
Coenzyme A
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The order of decreasing sequence rule precedence is
When the three-dimensional formula is viewed from a perspective in which the lowest ranked sub-
stituent is away from us, we see
The absolute configuration is R.
The conversion of L-glycerol 3-phosphate to a phosphatidic acid does not affect any of the bonds
to the stereogenic center, nor does it alter the sequence rule ranking of the substituents.
The absolute configuration is R.
26.5 Cetyl palmitate (hexadecyl hexadecanoate) is an ester in which both the acyl group and the alkyl
group contain 16 carbon atoms.
26.6 The structure of PGE
1
is found in text Figure 26.5.
The problem states that PGE
2
has one more double bond than PGE
1
and that it is biosynthesized
from arachidonic acid. Arachidonic acid (text Table 26.1) has a double bond at C-5, and thus PGE
2
has the structure shown.
several steps
Arachidonic acid
5
CH
3
COOH
PGE
2
OH
CH
3
COOH
HO
O
5
HO
O
COOH
OH
CH
3
PGE
1
CH
3
(CH
2
)
14
CO(CH
2
)
15
CH
3
O
Hexadecyl hexadecanoate
C
CH
2
OCR
H
RH11032CO
H
2
O
3
POCH
2
H
2
O
3
POCH
2
O
RH11032CO
O
O
H11022 H11022 H11022RCOCH
2
O
H
HOCH
2
OH
C
H
2
O
3
POCH
2
Order of decreasing rank is
clockwise, therefore R.
HO HH
2
O
3
POCH
2
HOCH
2
H11022 H11022 H11022
LIPIDS 733
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26.7 Isoprene units are fragments in the carbon skeleton. Functional groups and multiple bonds
are ignored when structures are examined for the presence of isoprene units.
H9251-Phellandrene (two equally correct answers):
Menthol (same carbon skeleton as H9251-phellandrene but different functionality):
Citral:
H9251-Selinene is shown in text Section 26.7.
Farnesol:
Abscisic acid:
Cembrene (two equally correct answers):
Vitamin A:
OH
or
OH
CO
2
H
O
OH
CH
O
or
OHOH
or
734 LIPIDS
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26.8 H9252-Carotene is a tetraterpene because it has 40 carbon atoms. The tail-to-tail linkage is at the midpoint
of the molecule and connects two 20-carbon fragments.
26.9 Isopentenyl pyrophosphate acts as an alkylating agent toward farnesyl pyrophosphate. Alkylation is
followed by loss of a proton from the carbocation intermediate, giving geranylgeranyl pyrophos-
phate. Hydrolysis of the pyrophosphate yields geranylgeraniol.
26.10 Borneol, the structure of which is given in text Figure 26.7, is a secondary alcohol. Oxidation of
borneol converts it to the ketone camphor.
OH
H
H
2
CrO
4
O
Borneol Camphor
OPP
HH
H11001
Geranylgeranyl pyrophosphate
OPP
Geranylgeraniol
OH
H11002H
H11001
H
2
O
Farnesyl pyrophosphate
OPP
Isopentenyl pyrophosphate
H11001
OPP
Tail-to-tail link between isoprene units
LIPIDS 735
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736 LIPIDS
Reduction of camphor with sodium borohydride gives a mixture of stereoisomeric alcohols, of
which one is borneol and the other isoborneol.
26.11 Figure 26.8 in the text describes the distribution of
14
C (denoted by *) in citronellal biosynthesized
from acetate enriched with
14
C in its methyl group.
If, instead, acetate enriched with
14
C at its carbonyl carbon were used, exactly the opposite distribu-
tion of the
14
C label would be observed.
When
14
CH
3
CO
2
H is used, C-2, C-4, C-6, C-8, and both methyl groups of citronellal are labeled.
When CH
3
14
CO
2
H is used, C-1, C-3, C-5, and C-7 are labeled.
26.12 (b) The hydrogens that migrate in step 3 are those at C-13 and C-17 (steroid numbering).
As shown in the coiled form of squalene 2,3-epoxide, these correspond to hydrogens at C-14
and C-18 (systematic IUPAC numbering).
(c) The carbon atoms that form the C, D ring junction in cholesterol are C-14 and C-15 of squalene
2,3-epoxide. It is the methyl group at C-15 of squalene 2,3-epoxide that becomes the methyl
group at this junction in cholesterol.
HO
H
CH
3
H11001
O
H
H
H
H11001
14
15 18
HO
H
H
13 17
H11001
*
***
CH
O
*
CH
3
CO
2
H
CH
3
CO
2
H
* CH
O
* *
* * **
NaBH
4
O
OH
H
Borneol
H
OH
IsoborneolCamphor
H11001
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(d) The methyl groups that are lost are the methyl substituents at C-2 and C-10 plus the methyl
group that is C-1 of squalene 2,3-epoxide.
26.13 Tracking the
14
C label of
14
CH
3
CO
2
H through the complete biosynthesis of cholesterol requires a
systematic approach. First, by analogy with Problem 26.11, we can determine the distribution of
14
C
(denoted by *) in squalene 2,3-epoxide.
Next, follow the path of the
14
C-enriched carbons in the cyclization of squalene 2,3-epoxide to
lanosterol.
***
*****
***
******
*
O
then on to
cholesterol
****
*
*
*
*
*
*
*
*
*
***
HO
H11001
** **
Lanosterol
****
*
*
*
*
*
*
*
*
*
*
HO
*
*
Cholesterol
*
*
*
*
*
*
*
*
HO
****
*
*
*
***
***
******
******
O
O
H
H11001
2
10
CH
3
CH
3
CH
3
LIPIDS 737
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26.14 By analogy to the reaction in which 7-dehydrocholesterol is converted to vitamin D
3
, the structure
of vitamin D
2
can be deduced from that of ergosterol.
26.15 (a) Fatty acid biosynthesis proceeds by the joining of acetate units.
Thus, the even-numbered carbons will be labeled with
14
C when palmitic acid is biosynthe-
sized from
14
CH
3
CO
2
H.
(b) As noted in Problem 26.6, arachidonic acid (Table 26.1) is the biosynthetic precursor of PGE
2
.
The distribution of the
14
C label in PGE
2
biosynthesized from
14
CH
3
CO
2
H reflects the fatty
acid origin of the prostaglandins.
(c) Limonene is a monoterpene, biosynthesized from acetate by way of mevalonate and isopen-
tenyl pyrophosphate.
14
CH
3
CO
2
H
Acetic acid Isopentenyl
pyrophosphate
OPP
*
* *
Limonene
*
*
*
*
*
*
*
***
*
**
*
*
*
PGE
2
OH
CH
3
COOH
HO
O
CH
3
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CH
2
CO
2
H
********
CH
3
CSCoA
O
CH
3
CCH
2
CSCoA
O
CH
3
(CH
2
)
14
CSCoA
OO
Acetyl coenzyme A Acetoacetyl coenzyme A Palmitoyl coenzyme A
light
7-Dehydrocholesterol
Vitamin D
3
HO
H H
HO
H
light
Ergosterol
Vitamin D
2
HO
H H
HO
H
738 LIPIDS
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(d) The distribution of the
14
C label in H9252-carotene becomes evident once its isoprene units are
identified.
26.16 The carbon chain of prostacyclin is derived from acetate by way of a C
20
fatty acid. Trace a contin-
uous chain of 20 carbons beginning with the carboxyl group. Even-numbered carbons are labeled
with
14
C when prostacyclin is biosynthesized from
14
CH
3
CO
2
H.
26.17 The isoprene units in the designated compounds are shown by disconnections in the structural
formulas.
(a) Ascaridole:
(b) Dendrolasin:
(c) H9253-Bisabolene
(d) H9251-Santonin
CH
3
CH
3
O
O
CH
3
O
or
O
or
O
O
O
O
Prostacyclin
HO
OH
COOH
CH
3
O
***
*
*
*
*
*
*
*
H9252-Carotene
* *
*
*
*
*
*
****
*
*
**
*
*
*
* *
*
*
*
*
LIPIDS 739
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(e) Tetrahymanol
26.18 Of the four isoprene units of cubitene, three of them are joined in the usual head-to-tail fashion, but
the fourth one is joined in an irregular way.
26.19 (a) Cinerin I is an ester, the acyl portion of which is composed of two isoprene units, as follows:
(b) Hydrolysis of cinerin I involves cleavage of the ester unit.
Chrysanthemic acid has the constitution shown in the equation. Its stereochemistry is revealed
by subsequent experiments.
1. O
3
2. oxidation
H11001
OO
COH
(H11001)-Chrysanthemic
acid
O
O
COH
HOC
(H11002)-Caronic acid
CH
3
CCH
3
Acetone
H
2
O
O
O
Cinerin I
H11001
O
COH
(H11001)-Chrysanthemic
acid
HO
O O
O
O
O
Cinerin I
Irregular linkage of this
isoprene unit to remainder
of molecule
H
3
C CH
3
CH
3
CH
3
CH
3
CH
3
OH
CH
3
H
3
C
Tail-to-tail linkage
of isoprene units
740 LIPIDS
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Because caronic acid is optically active, its carboxyl groups must be trans to each other. (The
cis stereoisomer is an optically inactive meso form.) The structure of (H11001)-chrysanthemic acid
must therefore be either the following or its mirror image.
The carboxyl group and the 2-methyl-1-propenyl side chain must be trans to each other.
26.20 (a) Hydrolysis of phrenosine cleaves the glycosidic bond. The carbohydrate liberated by this
hydrolysis is D-galactose.
Phrenosine is a H9252-glycoside of D-galactose.
(b) The species that remains on cleavage of the galactose unit has the structure
The two substances, sphingosine and cerebronic acid, that are formed along with D-galactose
arise by hydrolysis of the amide bond.
26.21 (a) Catalytic hydrogenation over Lindlar palladium converts alkynes to cis alkenes.
H11001 H
2
Lindlar Pd
(CH
2
)
7
COOHCH
3
(CH
2
)
7
HH
CC
(Z)-9-Octadecenoic acid (74%)
(oleic acid)
CH
3
(CH
2
)
7
C C(CH
2
)
7
COOH
9-Octadecynoic acid
(stearolic acid)
H11001
CH
3
(CH
2
)
12
CH CHCHOH
C
HOCH
2
NH
2
H
Sphingosine
O
HOCCH(CH
2
)
21
CH
3
OH
Cerebronic acid
CH
3
(CH
2
)
12
CH CHCHOH O
C
HOCH
2
NHCCH(CH
2
)
21
CH
3
H
OH
CHO
CH
2
OH
HO
HO H
OHH
H
HOH
H
HO OH
H
OH
H
CH
2
OH
H
H
OH
O
CO
2
H
H
H
LIPIDS 741
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(b) Carbon–carbon triple bonds are converted to trans alkenes by reduction with lithium and
ammonia.
(c) The carbon–carbon double bond is hydrogenated readily over a platinum catalyst. Reduction
of the ester function does not occur.
(d) Lithium aluminum hydride reduces the ester function but leaves the carbon–carbon double
bond intact.
(e) Epoxidation of the double bond occurs when an alkene is treated with a peroxy acid. The
reaction is stereospecific; substituents that are cis to each other in the alkene remain cis in the
epoxide.
( f ) Acid-catalyzed hydrolysis of the epoxide yields a diol; its stereochemistry corresponds to net
anti hydroxylation of the double bond of the original alkene.
The product is chiral but is formed as a racemic mixture containing equal amounts of the
9R,10R and 9S,10S stereoisomers when the starting epoxide is racemic.
9,10-Dihydroxyoctadecanoic acid
C
(CH
2
)
7
COOH
HO
H
H
CH
3
(CH
2
)
7
OH
H
3
O
H11001
C
cis-9,10-Epoxyoctadecanoic acid
C
H
H
CH
3
(CH
2
)
7 (CH
2
)
7
COOH
O
C
H11001(Z)-CH
3
(CH
2
)
7
CH CH(CH
2
)
7
COOH
Oleic acid
C
6
H
5
CO
2
OH
Peroxybenzoic
acid
H11001
Benzoic acid
C
6
H
5
COH
O
cis-9,10-Epoxyoctadecanoic acid
(62–67%)
C
H
H
CH
3
(CH
2
)
7 (CH
2
)
7
COOH
O
C
(Z)-CH
3
(CH
2
)
5
CHCH
2
CH CH(CH
2
)
7
COCH
3
O
OH
Methyl (Z)-12-hydroxy-9-octadecenoate
(methyl ricinoleate)
H11001(Z)-CH
3
(CH
2
)
5
CHCH
2
CH CH(CH
2
)
7
CH
2
OH
OH
(Z)-9-Octadecen-1,12-diol (52%)
CH
3
OH
Methanol
1. LiAlH
4
2. H
2
O
(Z)-CH
3
(CH
2
)
7
CH CH(CH
2
)
7
COCH
2
CH
3
O
Ethyl (Z)-9-octadecenoate
(ethyl oleate)
CH
3
(CH
2
)
16
COCH
2
CH
3
O
Ethyl octadecanoate (91%)
(ethyl stearate)
H
2
, Pt
(CH
2
)
7
COOH
CH
3
(CH
2
)
7
H
H
CC
(E)-9-Octadecenoic acid (97%)
(elaidic acid)
CH
3
(CH
2
)
7
C C(CH
2
)
7
COOH
9-Octadecynoic acid
(stearolic acid)
1. Li, NH
3
2. H
H11001
742 LIPIDS
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(g) Hydroxylation of carbon–carbon double bonds with osmium tetraoxide proceeds with syn ad-
dition of hydroxyl groups.
The product is chiral but is formed as a racemic mixture containing equal amounts of the
9R,10S and 9S,10R stereoisomers.
(h) Hydroboration–oxidation gives syn hydration of carbon–carbon double bonds with a regio-
selectivity contrary to Markovnikov’s rule. The reagent attacks the less hindered face of the
double bond of H9251-pinene.
(i) The starting alkene in this case is H9252-pinene. As in the preceding exercise with H9251-pinene, diborane
adds to the bottom face of the double bond.
( j) The starting material is an acetal. It undergoes hydrolysis in dilute aqueous acid to give a
ketone.
H
3
O
H11001
2CH
3
OH H11001
H
3
C
H
3
C
CH
3
O
CH
3
O
H
3
C
OH
H
3
C
OH
H
HH
H
H
3
C
O
H
3
C
H
HH
H
(95% yield)
1. B
2
H
6
, diglyme
2. H
2
O
2
, HO
H11002
CH
2
CH
3
CH
3
B
2
H
6
attacks from
this direction.
Methyl group shields top
face of double bond.
cis-Myrtanol (81%)
CH
3
H
3
C
HOCH
2
H
1. B
2
H
6
, diglyme
2. H
2
O
2
, HO
H11002
CH
3
H
3
C
H
3
C
HO
H
H
Isopinocampheol (79%)
H
CH
3
CH
3
CH
3
B
2
H
6
attacks from
this direction.
Methyl group shields top
face of double bond.
9,10-Dihydroxyoctadecanoic acid
(70%)
CC
OHHO
H H
CH
3
(CH
2
)
7
(CH
2
)
7
COOH
(Z)-CH
3
(CH
2
)
7
CH CH(CH
2
)
7
COOH
1. OsO
4
, (CH
3
)
3
COOH, HO
H11002
2. H
H11001
LIPIDS 743
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26.22 (a) There are no direct methods for the reduction of a carboxylic acid to an alkane. A number of
indirect methods that may be used, however, involve first converting the carboxylic acid to an
alkyl bromide via the corresponding alcohol.
Once the alkyl bromide is in hand, it may be converted to an alkane by conversion to a Grignard
reagent followed by addition of water.
Other routes are also possible. For example, E2 elimination from 1-bromooctadecane
followed by hydrogenation of the resulting alkene will also yield octadecane.
(b) Retrosynthetic analysis reveals that the 18-carbon chain of the starting material must be attached
to a benzene ring.
The desired sequence may be carried out by a Friedel–Crafts acylation, followed by Clemmensen
or Wolff–Kishner reduction of the ketone.
(c) First examine the structure of the target molecule 3-ethylicosane.
Retrosynthetic analysis reveals that two ethyl groups have been attached to a C
18
unit.
CH
3
(CH
2
)
16
CH CH
3
(CH
2
)
16
CH H11001
CH
2
CH
3
CH
2
CH
3
2CH
3
CH
2
CH
3
(CH
2
)
16
CHCH
2
CH
3
CH
2
CH
3
CH
3
(CH
2
)
16
CO
2
HCH
3
(CH
2
)
16
CCl
O
C(CH
2
)
16
CH
3
O
CH
2
(CH
2
)
16
CH
3
SOCl
2 benzene
AlCl
3
Octadecanoic acid Octadecanoyl chloride 1-Phenyl-1-octadecanone
1-Phenyloctadecane
Zn(Hg), HCl
1-Phenyloctadecane
(CH
2
)
17
CH
3
H11001 (CH
2
)
17
CH
3
CH
3
(CH
2
)
16
CH
2
Br
1-Bromooctadecane
CH
3
(CH
2
)
16
CH
2
MgBr CH
3
(CH
2
)
16
CH
3
Octadecane
H
2
O
Mg
diethyl ether
CH
3
(CH
2
)
16
CO
2
H
Octadecanoic acid
CH
3
(CH
2
)
16
CH
2
OH
1-Octadecanol
CH
3
(CH
2
)
16
CH
2
Br
1-Bromooctadecane
1. LiAlH
4
2. H
2
O
HBr, heat
or PBr
3
744 LIPIDS
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The necessary carbon–carbon bonds can be assembled by the reaction of an ester with two
moles of a Grignard reagent.
With the correct carbon skeleton in place, all that is needed is to convert the alcohol to the
alkene. This can be accomplished by dehydration and reduction.
(d) Icosanoic acid contains two more carbon atoms than octadecanoic acid.
A reasonable approach utilizes a malonic ester synthesis.
CH
3
(CH
2
)
16
CH
2
Br CH
3
(CH
2
)
16
CH
2
CH(CO
2
CH
2
CH
3
)
2
CH
2
(CO
2
CH
2
CH
3
)
2
H11001
NaOCH
2
CH
3
1-Bromooctadecane
[prepared as in part (a)]
Diethyl malonate Diethyl 2-octadecylmalonate
CH
3
(CH
2
)
16
CH
2
CH
2
CO
2
H
Icosanoic acid
1. HO
H11002
, H
2
O
2. H
H11001
3. heat
CH
3
(CH
2
)
18
CO
2
HCH
3
(CH
2
)
16
CH
2
Br H11001 CH
2
CO
2
H
H11002
Icosanoic acid
CH
3
(CH
2
)
16
CCH
2
CH
3
OH
CH
2
CH
3
3-Ethyl-3-icosanol 3-Ethyl-2-icosene 3-Ethyl-3-icosene
H
2
SO
4
heat
H11001CH
3
(CH
2
)
16
C CHCH
3
CH
2
CH
3
CH
3
(CH
2
)
15
CH CCH
2
CH
3
CH
2
CH
3
CH
3
(CH
2
)
16
CHCH
2
CH
3
CH
2
CH
3
3-Ethylicosane
H
2
, Pt
CH
3
(CH
2
)
16
COCH
2
CH
3
2CH
3
CH
2
MgBr
1. diethyl ether
2. H
3
O
H11001
O
H11001 CH
3
(CH
2
)
16
CCH
2
CH
3
OH
CH
2
CH
3
Ethyl octadecanoate
(from octadecanoic acid
and ethanol)
Ethylmagnesium
bromide
3-Ethyl-3-icosanol
LIPIDS 745
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(e) The carbon chain must be shortened by one carbon atom in this problem. A Hofmann rearrange-
ment (text Section 20.17) is indicated.
( f ) Lithium aluminum hydride reduction of octadecanamide gives the corresponding amine.
(g) Chain extension can be achieved via cyanide displacement of bromine from 1-bromoocta-
decane. Reduction of the cyano group completes the synthesis.
26.23 First acylate the free hydroxyl group with an acyl chloride.
Treatment with aqueous acid brings about hydrolysis of the acetal function.
The two hydroxyl groups of the resulting diol are then esterified with 2 moles of the second acyl
chloride.
26.24 The overall transformation
to
OH SCH
3
H11001HOCH
2
CHCH
2
OCR
O
OH RH11032CO
O
RH11032COCH
2
CHCH
2
OCR
OO
2RH11032CCl
O
O
OH
HOCH
2
CHCH
2
OCR H11001
O
CH
3
CCH
3
O
OO
CH
2
OCR
CH
3
H
3
C
H
3
O
H11001
H11001
O
RCCl
OO
CH
2
OH
CH
3
H
3
C
O
OO
CH
2
OCR
CH
3
H
3
C
CH
3
(CH
2
)
16
CH
2
Br
1-Bromooctadecane
[from part (a)]
CH
3
(CH
2
)
16
CH
2
C
Nonadecanenitrile
KCN
N CH
3
(CH
2
)
16
CH
2
CH
2
NH
2
1-Nonadecanamine
1. LiAlH
4
2. H
2
O
CH
3
(CH
2
)
16
CNH
2
CH
3
(CH
2
)
16
CH
2
NH
2
O
Octadecanamide
[from part (e)]
1-Octadecanamine
1. LiAlH
4
2. H
2
O
CH
3
(CH
2
)
16
CO
2
HCH
3
(CH
2
)
16
CNH
2
CH
3
(CH
2
)
16
NH
2
O
Octadecanoic acid Octadecanamide 1-Heptadecanamine
Br
2
, HO
H11002
1. SOCl
2
2. NH
3
746 LIPIDS
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requires converting the alcohol function to some suitable leaving group, followed by substitution by
an appropriate nucleophile.
As reported in the literature, the alcohol was converted to its corresponding p-toluenesulfonate ester
and this substance was then used as the substrate in the nucleophilic substitution step to produce the
desired sulfide in 76% yield.
26.25 The first transformation is an intramolecular aldol condensation. This reaction was carried out under
conditions of base catalysis.
The next step is reduction of a ketone to a secondary alcohol. Lithium aluminum hydride is suitable;
it reduces carbonyl groups but leaves the double bond intact.
Conversion of an alkene to a cyclopropane can be accomplished to using the Simmons–Smith
reagent (iodomethylzinc iodide).
Oxidation of the secondary alcohol to the ketone can be accomplished with any of a number of
oxidizing agents. The chemists who reported this synthesis used chromic acid.
H
2
CrO
4
, H
2
SO
4
H
2
O, acetone
5-Isopropylbicyclo-
[3.1.0]hexan-2-ol
OH
5-Isopropylbicyclo[3.1.0]hexan-2-one
(89%)
O
CH
2
I
2
Zn(Cu)
3-Isopropyl-2-
cyclopenten-1-ol
OH
5-Isopropylbicyclo[3.1.0]hexan-2-ol
(66%)
OH
1. LiAlH
4
2. H
2
O
3-Isopropyl-2-
cyclopentenone
O
3-Isopropyl-2-
cyclopenten-1-ol (97%)
OH
NaOH
H
2
O, ethanol
H11002H
2
O
6-Methyl-2,5-
heptanedione
O
O
(Not isolated)
HO
O
3-Isopropyl-2-
cyclopentenone (71%)
O
PBr
3
NaSCH
3
OH
3-Methyl-3-buten-1-ol
Br
4-Bromo-2-methyl-
1-butene
SCH
3
3-Methyl-3-butenyl
methyl sulfide
LIPIDS 747
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A Wittig reaction converts the ketone to sabinene.
26.26 The first step is a 1,4 addition of hydrogen bromide to the conjugated diene system of isoprene.
This is followed by Markovnikov addition of hydrogen bromide to the remaining double bond.
26.27 A reasonable mechanism is protonation of the isolated carbon–carbon double bond, followed by
cyclization.
H
O
H OSO
2
OH
H11002H
H11001
H9252-Ionone
O
H9251-Ionone
O
O
H11001
O
H11001
CH
3
CCH
2
CH
2
Br
CH
3
Br
H11002
H11001
CH
3
CCH
2
CH
2
Br
CH
3
Br
1,3-Dibromo-3-
methylbutane
CH
3
C
CH
3
CHCH
2
Br HBr
1-Bromo-3-methyl-
2-butene
Hydrogen
bromide
Br H H11001 CH
2
CH
2
CH
3
CCH
2
CHCCH
CH
3
CH
3
CH
3
CCH
2
BrCH
CH
3
H11001
H11002
Br
Hydrogen
bromide
2-Methyl-
1,3-butadiene
1-Bromo-3-
methyl-2-butene
(C
6
H
5
)
3
PCH
2
H11001
H11002
5-Isopropylbicyclo-
[3.1.0]hexan-2-one
O
Sabinene
(70%)
CH
2
748 LIPIDS
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26.28 The double bond has a tendency to become conjugated with the carbonyl group. Two mechanisms
are more likely than any others under conditions of acid catalysis. One of these involves protonation
of the double bond followed by loss of a proton from C-4.
The other mechanism proceeds by enolization followed by proton-induced double-bond migration.
26.29 See the June, 1995, issue of the Journal of Chemical Education, pages 541–542, for the solution to
this problem.
26.30 Solutions to molecular modeling exercises are not provided in this Study Guide and Solutions Man-
ual. You should use Learning By Modeling for this exercise.
SELF-TEST
PART A
A-1. Write a balanced chemical equation for the basic hydrolysis of tristearin.
A-2. Both waxes and fats are lipids that contain the ester functional group. In what way do the
structures of these lipids differ?
A-3. Classify each of the following isoprenoid compounds as a monoterpene, a diterpene, and so
on. Indicate with dashed lines the isoprene units that make up each structure.
(b) Caryophyllene:
Abietic acid:(c)
CO
2
H
(a) H9251-Pinene:
H
3
O
H11001
H11002H
H11001
H
3
O
H11001
O
H
3
C
O
H
3
C
HO
H
3
C
HOH
2
H11001
HH
H11001
HO
H
3
C
HH
H11001
O
H
H
3
C
HH HH
H11001
O
H
3
C
O
H
3
C
O
H
3
C
H
H
HO
H11001
H11002H
H11001
LIPIDS 749
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A-4. Propose a series of synthetic steps to carry out the preparation of oleic acid [(Z)-9-octa-
decenoic acid] from compound A. You may use any necessary organic or inorganic reagents.
A-5. Write a mechanism for the biosynthetic pathway by which limonene is formed from geranyl
pyrophosphate.
PART B
B-1. A major component of a lipid bilayer is
(a) A triacylglycerol such as tristearin
(b) Phosphatidylcholine, also known as lecithin
(c) A sterol such as cholesterol
(d) A prostaglandin such as PGE
1
B-2. Compare the following two triacylglycerols:
(a) The melting point of A will be higher.
(b) The melting point of B will be higher.
(c) The melting points of A and B will be the same.
(d) No comparison of melting points can be made.
B-3. Lanosterol, a biosynthetic precursor of cholesterol, exists naturally as a single enantiomer.
How many possible stereoisomers having the lanosterol skeleton are there?
(a)7 (b)64 (c) 128 (d) 256
HO
Lanosterol
CH
2
O
2
CC
17
H
35
CH
2
O
2
CC
17
H
31
CHO
2
CC
17
H
31
B
CH
2
O
2
CC
17
H
35
CH
2
O
2
CC
17
H
35
CHO
2
CC
17
H
35
A
OPP
Geranyl pyrophosphate Limonene
O
O
C(CH
2
)
7
CHHC
A
750 LIPIDS
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B-4. The compound whose carbon skeleton is shown, known as selinene, is found in celery.
This substance is an example of a
(a) Monoterpene (c) Sesquiterpene
(b) Diterpene (d) Triterpene
B-5. Which of the following correctly represents the isoprenoid units of selinene?
(a)(c) Both of these are acceptable
(b)(d) Neither of these is acceptable
B-6. What is the distribution of radioactive carbon (
14
C) in isopentenyl pyrophosphate biosynthe-
sized from acetic acid labelled with
14
C at its carboxyl carbon (CH
3
C
*
O
2
H)?
14
C is indicated
by an asterisk (*) in the structures.
(a)(d)
(b e)
(c)
OPP
*
*
*
OPP
**
*
OPP
*
**
OPP
*
*
OPP
**
LIPIDS 751
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