Preface to the
Second Edition
The second edition ofthe Fermentation andBiochemica1 Engineer-
ing Handbook, like the previous edition, is intended to assist the develop-
ment, design and production engineer who is engaged in the fermentation
industry. Particular emphasis is give to those unit operations most frequently
encountered in the commercial production ofchemicals and pharmaceuticals
via fermentation, separation, and purification.
Some theory is included to provide the necessary insight into the
unit operation but is not emphasized. Rather, the emphasis is placed on
the practical aspects of development, design and operation-how one
goes about collecting design data, what are the scale-up parameters, how
to select the right piece of equipment, where operating problems arise,
and how to troubleshoot.
The text is written from a practical and operating viewpoint, and
all of the contributing authors have been chosen because of their
industrial background and orientation. Several of the chapters which
were in the first edition have been either deleted or replaced by other
chapters which are more germane to current fermentation practice.
Those chapters which were retained have been updated or have been
rewritten to reflect current practice. Several new chapters were intro-
duced to reflect current emphasis on cell cultures, nutritional require-
ments, statistical methods for fermentation optimization, cross-flow
filtration, environmental concerns, and plant design
vi
Preface to the Second Edition vii
The editors wish to express their gratitude to Mrs. Connie Gaskill
of Heinkel Filtering Systems, Inc., for the wordprocessing assistance she
gave to this edition.
Scotch Plains, New Jersey
Bridgeport, New Jersey
September, 1996
Henry C. Vogel
Celeste L. Todaro
Preface to the
First Edition
This book is intended to assist the development, design and produc-
tion engineer who is engaged in the fermentation industry. Particular
emphasis is given to those unit operations most frequently encountered in the
commercial production of chemicals and pharmaceuticals via fermentation,
separation, and purification.
Some theory is included to provide the necessary insight into the unit
operation but is not emphasized. Rather, the emphasis is placed on the
practical aspects of development, design and operation-how one goes about
collecting design data, what are the scale-up parameters, how to select the
right piece of equipment, where operating problems arise and how to
troubleshoot.
The text is written from a practical and operating viewpoint, and all
of the contributing authors have been chosen because of their industrial
background and orientation. Since the handbook concerns fermentation and
often the engineers involved in fermentation are not versed in microbiology,
it was thought advisable to introduce this subject at the beginning ofthe book.
Similarly, since much of fermentation deals with the production of antibiot-
ics, it was deemed advisable to include some chapters specifically oriented to
the production of sterile products.
The engineering using this handbook may wish that other unit
operations or different pieces of equipment had been included other than those
viii
Preface to the First Edition ix
selected. The selection was based on the individual contributors and my own
experience, over many years of work in the field, with unit operations and
pieces of equipment that have been the backbone and workhorses of the
industry.
The editor wished to express his thanks to Mr. Stanley Grossel of
HofEnann-La Roche and Mr. John Carney of Davy McKee Corporation for
reviewing and editing the draft copies. He also thanks Miss Mary Watson of
Davy McKee Corporation for typing assistance, and Mr. Michael Garze of
Davy McKee Corporation for his help in producing many of the graphs and
illustrations. Dr. Sol Barer, the author ofthe microbiology chapter acknowl-
edges the valuable input to the Celanese Biotechnology Department, and
especially thanks Miss Maria Guerra for her patience in typing and retyping
the manuscript.
Berkeley Heights, New Jersey
June 1983
Henry C. Vogel