Chapter 2
Tissue repair
Department of pathology longjie
Repair (修复）
Would healing （创伤愈合）
Repair (修复）
As cells and tissues are being injured,
events that contain the damage and
prepare the surviving cells to replicate are
set into motion.
Repair begins very early in the cell injury,
and involves two processes:
1,Regeneration (再生）
2,fibrosis （纤维性修复）
regeneration
再 生
Regeneration of injured tissue by
parenchymal cells of the same type,
types
Physiological regeneration
Pathological regeneration
Proliferative
potential of different
cell types
Labile
cells
Stable
cells
Permanent cells
不稳定细胞
稳定细胞
永久性细胞
Labile cells
? Continuously dividing and dying
? Surface epithelia
stratified squamous surfaces
cuboidal epithelia
columnar epithlium
transitional epithelium
? Hematopoietic cells
Stable cells
? Quiescent but can rapidly divide in response to
injury
? Parenchymal of solid glandular tissues,liver,
kidney,pancreas
? Endothelial cells lining blood vessels
? fibroblast
? Smooth muscle connective tissue
Permanent cells
? Be terminally differentiated and
nonproliferative in postnatal life
? neurons
? Cardiac muscle cells
Regeneration of
different tissues
毛细血管的再生 angiogenesis
fibrosis
纤维性修复
Replacement by connective tissue,
resulting in a scar.
types
Granulation tissue (肉芽组织 )
Scar (瘢痕 )
?Gross,pink,soft,granular
?Micro:
proliferation of fibroblasts
new thin-walled,delicate capillaries
inflammatory cells
Granulation tissue
脚
的
肉
芽
组
织
肉
芽
组
织
Granulation tissue
fibroblast
signafication
? risist infection and protect the wound
surface；
? fill the deficiency and repair the injured
tissue；
? organize blood clotting,necrotic tissues or
abnormal substances
?Gross,tissue shrinkage,pale-gray,
hard,lack of elasticity
?Micro:
fibroblasts,new vessels avascular
inflammatory cells
collagen synthesis hyaline change
scar
effect
Good,1.fill the defect,repair the tissue
2,More tensile strength than granulation tissue
bad,1.scar shrinkage obstruction of tissue activity
2,Scaring conglutination ( 瘢痕性粘连）
3,Organ cirrosis （器官硬化）
4,Scar hyperplasia （瘢痕增生）
Wound Healing
A complex but orderly process,
involving both parenchymal cells
regeneration and the formation of
connective tissue scar.(创伤愈合 )
Healing of skin wound
types
Healing by first intention (primary union)
一期愈合
Healing by second intention (sceondary union)
二期愈合
Healing of a clean,
uninfected surgical incision
approximated by surgical
sutures.
1,Less fibrinclotted blood,
granulation tissue and scar
2,Mild inflammation reaction
一
期
愈
合
模
式
图
large tissue defects,
infected and irregular
incision.
1,Much larger amounts of
granulation tissue and scar
2,Extensive inflammation
reaction
二
期
愈
合
模
式
图
Healing of skin wound
influences of
healingAge
nutrition
infection
Blood
supply
radiation
glucocorticoids
Mechanical
factors
Healing of bone fracture
(self – study)
Tissue repair
Department of pathology longjie
Repair (修复）
Would healing （创伤愈合）
Repair (修复）
As cells and tissues are being injured,
events that contain the damage and
prepare the surviving cells to replicate are
set into motion.
Repair begins very early in the cell injury,
and involves two processes:
1,Regeneration (再生）
2,fibrosis （纤维性修复）
regeneration
再 生
Regeneration of injured tissue by
parenchymal cells of the same type,
types
Physiological regeneration
Pathological regeneration
Proliferative
potential of different
cell types
Labile
cells
Stable
cells
Permanent cells
不稳定细胞
稳定细胞
永久性细胞
Labile cells
? Continuously dividing and dying
? Surface epithelia
stratified squamous surfaces
cuboidal epithelia
columnar epithlium
transitional epithelium
? Hematopoietic cells
Stable cells
? Quiescent but can rapidly divide in response to
injury
? Parenchymal of solid glandular tissues,liver,
kidney,pancreas
? Endothelial cells lining blood vessels
? fibroblast
? Smooth muscle connective tissue
Permanent cells
? Be terminally differentiated and
nonproliferative in postnatal life
? neurons
? Cardiac muscle cells
Regeneration of
different tissues
毛细血管的再生 angiogenesis
fibrosis
纤维性修复
Replacement by connective tissue,
resulting in a scar.
types
Granulation tissue (肉芽组织 )
Scar (瘢痕 )
?Gross,pink,soft,granular
?Micro:
proliferation of fibroblasts
new thin-walled,delicate capillaries
inflammatory cells
Granulation tissue
脚
的
肉
芽
组
织
肉
芽
组
织
Granulation tissue
fibroblast
signafication
? risist infection and protect the wound
surface；
? fill the deficiency and repair the injured
tissue；
? organize blood clotting,necrotic tissues or
abnormal substances
?Gross,tissue shrinkage,pale-gray,
hard,lack of elasticity
?Micro:
fibroblasts,new vessels avascular
inflammatory cells
collagen synthesis hyaline change
scar
effect
Good,1.fill the defect,repair the tissue
2,More tensile strength than granulation tissue
bad,1.scar shrinkage obstruction of tissue activity
2,Scaring conglutination ( 瘢痕性粘连）
3,Organ cirrosis （器官硬化）
4,Scar hyperplasia （瘢痕增生）
Wound Healing
A complex but orderly process,
involving both parenchymal cells
regeneration and the formation of
connective tissue scar.(创伤愈合 )
Healing of skin wound
types
Healing by first intention (primary union)
一期愈合
Healing by second intention (sceondary union)
二期愈合
Healing of a clean,
uninfected surgical incision
approximated by surgical
sutures.
1,Less fibrinclotted blood,
granulation tissue and scar
2,Mild inflammation reaction
一
期
愈
合
模
式
图
large tissue defects,
infected and irregular
incision.
1,Much larger amounts of
granulation tissue and scar
2,Extensive inflammation
reaction
二
期
愈
合
模
式
图
Healing of skin wound
influences of
healingAge
nutrition
infection
Blood
supply
radiation
glucocorticoids
Mechanical
factors
Healing of bone fracture
(self – study)
